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izvor podataka: crosbi

Olanzapine versus fluphenazine in an open trial in patients with psychotic combat-related posttraumatic stress disorder (CROSBI ID 104805)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pivac, Nela ; Kozarić-Kovačić, Dragica ; Muck-Šeler, Dorotea Olanzapine versus fluphenazine in an open trial in patients with psychotic combat-related posttraumatic stress disorder // Psychopharmacology, 175 (2004), 4; 451-456-x

Podaci o odgovornosti

Pivac, Nela ; Kozarić-Kovačić, Dragica ; Muck-Šeler, Dorotea

engleski

Olanzapine versus fluphenazine in an open trial in patients with psychotic combat-related posttraumatic stress disorder

Rationale Combat-related posttraumatic stress disorder (PTSD) is often complicated with other psychiatric comorbidities, and refractory to treatment. Objective The aim of an open, comparative 6-week study was to compare olanzapine and fluphenazine, as a monotherapy, for treating psychotic combat-related PTSD. Method Fifty-five male war veterans with psychotic PTSD (DSM-IV criteria) were treated for 6 weeks with olanzapine (N=28) or fluphenazine (N=27) in a 5-10 mg/day dose range, once or twice daily. Patients were evaluated at baseline, and after 3 and 6 weeks of treatment, using Watson's PTSD scale, Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Severity Scale (CGI-S), Clinical Global Impression Improvement Scale (CGI-I), Patient Global Impression Improvement Scale (PGI-I) and Drug Induced Extra-Pyramidal Symptoms Scale (DIEPSS). Results At baseline, patient's data (age, duration of combat experience and scores in all measurement instruments) did not differ. After 3 and 6 weeks of treatment, olanzapine was significantly more efficacious than fluphenazine in reducing symptoms in PANSS (negative, general psychopathology subscale, supplementary items), Watson's PTSD (avoidance, increased arousal) subscales, CGI-S, CGI-I, and PGI-I scale. Both treatments affected similarly the symptoms listed in PANSS positive and Watson's trauma reexperiencing subscales. Fluphenazine induced more extrapyramidal symptoms. Prolongation of the treatment for 3 additional weeks did not affect the efficacy of either drug. Conclusions Our data indicate that both fluphenazine and olanzapine were effective for particular symptom profile in psychotic combat-related PTSD. Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.

Combat-Related Posttraumatic Stress Disorder; Psychotic symptoms; Olanzapine; Fluphenazine

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Podaci o izdanju

175 (4)

2004.

451-456-x

objavljeno

0033-3158

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost