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Pd(II) coordination chemistry of ethyl 8-quinolylmethylphosphonate

The synthesis, spectroscopic and biological properties of palladium(II) halide complexes of ethyl 8-quinolylmethylphosphonate have been reported. It was shown that depending on the acidity of the reaction medium, the molecular or the ionic complexes could be obtained. A detailed infrared, electronic, mass and nuclear magnetic resonance spectroscopic studies, accompanied by the thermal, magnetic and conductometric measurements, have been applied for identification and characterization of the novel complexes. The in vitro antitumor activity of complexes was evaluated against KB and L1210 cell lines as a preliminary screening for their biological activity, and the results obtained were compared with those obtained for the complexes of diethyl 8-quinolylmethylphosphonate (8-dqmp).

palladium(II) complex; quinolylmethylphosphonate; antitumor activity; spectroscopic study

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