engleski

A study of some enzyme activities associated with theophylline administration.

In this study, rats were given theophylline at a dose of 15 mg/kg body mass in order to assess the possible adverse effects of the drug. Catalytic activities of AST, ALT, LDH and ALP were measured in the serum and liver of the animals at various time intervals (45, 60 and 300 min). The cumulative effect of theophylline, after a three-day application of the drug, was also studied. Livers of all studied animals were histopathologically examined. The catalytic acitivities of AST and LDH were increased in serum as early as after 60 min, and ALP in liver. Pathohystologic examination of the liver following the cumulative effect of theophylline revealed mild degenerative alterations. With increased doses of theophylline, undesired effects of the drug on the liver could be relativel< early predicted by the measurement of catalytic activities of AST and LDH in serum

theophylline ; enzyme activities ; rats

Rad u čsopisu prema Pravilniku NN 2/97.