Long-term follow-up study of children with lower grade peri-intraventricular haemorrhage: neurological and structural outcome (CROSBI ID 495272)
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Podaci o odgovornosti
Gojmerac, Tomislav ; Mejaški-Bošnjak, Vlatka ; Radoš, Marko ; Kostović, Ivica
engleski
Long-term follow-up study of children with lower grade peri-intraventricular haemorrhage: neurological and structural outcome
Object was to investigate the long-term neurodevelopmental outcome and structural reorganization of the brain in a cohort of perinatal risk neonates with lower grade peri-intraventricular hemorrhage diagnosed by ultrasound. One hundred thirty-seven perinatal risk children were multidisciplinary and ultrasonographically followed by the age of 2 years. At age of 13 to 16 years neurodevelopmental outcome was determined by follow-up examination of neurological status (Touwen) and visual acuity (Snellen charts). The information about epilepsy was obtained from EEG findings and medical reports. Morphology of the brain assessed by MR scans, performed on high-resolution 2T machine. Fifty-six children had peri-intraventricular hemorrhage grade I or II according to Papile, of whom long-term follow up were evaluated for 33 children (58, 9%): 12 children was born at <33 weeks’ gestation, 9 at 33-37 weeks and 10 were term. Mean ages at last assessment were 14 years and 2 months (s.d. ± ; ; 7, 5 months). In none of the children examined cerebral palsy was found, but 22 had minor neurological deficit (66, 7%): 13 MND1 and 9 MND2. Visual impairment was found in thirteen children (39, 4%) and epilepsy or pathologic EEG without seizures in three (9, 1%). Structural changes on MRI scans had 28 children (84, 8%): the most common changes were white matter hyperintensity (78, 8%), ventriculomegaly (57, 6%), reduction in the amount of periventricular white matter (51, 5%) and thinning of corpus callosum (18, 2%). No significant differences were found in long-term neurodevelopmental and structural outcome in depend on weeks’ gestation (p >0, 05). Our results indicated that even children with lower grade peri-intraventricular hemorrhage have relatively high percentage neurological deviant signs as well as brain structural changes. This unexpected high percentage deficits could be explained with concomitant hypoxic-ischemic lesions, present in some of the children examined.
Long-term follow up; Peri-intraventricular haemorrhage; Neurologicval outcome; Structural outcome
DOI: 10.1111/j.1469-8749.2003.tb04604.
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Podaci o prilogu
41-42.
2003.
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objavljeno
Podaci o matičnoj publikaciji
Developmental medicine and child neurology
0012-1622
Podaci o skupu
Nepoznat skup
poster
29.02.1904-29.02.2096
Povezanost rada
Kliničke medicinske znanosti