engleski

A value of cystatin C as a marker of glomerular filtration

Cystatin C, a low molecular mass endogenous protein, is a novell marker of glomerular filtration rate. However, it is still uncertain whether cystatin C has advantage over serum creatinine concentration, creatinine clearance measurement, as well as creatinine clearance estimation using Cockroft-Gault formula in evaluation of renal function. In the present study we prospectively compared above parameters to creatinine clearance determination in 89 patients with various degrees of renal function (Table1). A Value of Serum Cystatin C, Serum Creatinine and Cockroft-Gault Formula in Assessment of Glomerular Filtration With Respect to Creatinine Clearance Sensitivity (%) Specificity (%) Positive Predictive Value (%) Negative Predictive Value (%) Serum Cystatin C (mg/L) 66, 2 95, 8 97, 7 51, 1 Serum Creatinine (umol/L) 61, 5 100, 0 100, 0 49, 0 Cockroft-Gault Formula 86, 2 62, 5 86, 2 62, 5 In comparison to creatinine clearance, as a clinical gold standard for determination of glomerular filtration, serum cystatin C and creatinine concentrations were equally less sensitive markers. Therefore, cystatin C has no advantage over serum creatinine measurement and cannot replace determination of creatinine clearance as a clinical marker of glomerular filtration rate.

Cystatin C; glomerular filtration

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