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Novel cyano- and amidino-substituted styrylbenzothiazoles and their biological activity


Ćaleta, Irena; Karminski-Zamola, Grace; Grdiša, Mira; Pavelić, Krešimir
Novel cyano- and amidino-substituted styrylbenzothiazoles and their biological activity // 13th European simposium on organic chemistry : programme & abstracts / Šunjić, Vitomir (ur.).
Zagreb, 2003. str. 374-374 (poster, sažetak, ostalo)


Naslov
Novel cyano- and amidino-substituted styrylbenzothiazoles and their biological activity

Autori
Ćaleta, Irena ; Karminski-Zamola, Grace ; Grdiša, Mira ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
13th European simposium on organic chemistry : programme & abstracts / Šunjić, Vitomir - Zagreb, 2003, 374-374

Skup
European simposium on organic chemistry (13 ; 2003)

Mjesto i datum
Dubrovnik - Cavtat, Hrvatska, 10.-15.09.2003.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Neobjavljeni rad

Ključne riječi
Styrylbenzothiazoles; amidines; biological activity

Sažetak
A large number of benzothiazole derivatives are of considerable biological and chemical interest. Their pharmaceutical and agrochemical applications are of particular relevance. In order to find a new biologically active benzothiazole compounds we prepared in the multistep synthesis a serie of new styrylbenzothiazole compounds 1-9 starting from 6-cyano-2-methylbenzothiazole or 2-methylbenzothiazole and corresponding benzaldehydes. Cyano-derivatives of styrylbenzothiazoles 1-3 were converted by Pinner reaction into the corresponding amidine hydrochlorides 4-9. All styrylbenzothiazole compounds were tested on their antitumor activity. All compounds were characterized by means of IR, 1H- and 13C-NMR spectroscopy and elemental analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0125005

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb