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Pregled bibliografske jedinice broj: 138333

B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen


Kardum, Mirjana Mariana; Šiftar, Zoran; Nazor, Aida; Marić-Bešić, Kriskina; Radić-Krišto, Delfa; Jakšić, Branimir
B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen // Biochemia Medica, 3-4 (2002), 12; 81-85 (podatak o recenziji nije dostupan, članak, stručni)


CROSBI ID: 138333 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen

Autori
Kardum, Mirjana Mariana ; Šiftar, Zoran ; Nazor, Aida ; Marić-Bešić, Kriskina ; Radić-Krišto, Delfa ; Jakšić, Branimir

Izvornik
Biochemia Medica (9999-9999) 3-4 (2002), 12; 81-85

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
B-chronic lymphocytic leukemia; FCM; aberrant expression; CD8 antigen

Sažetak
SUMMARY - OBJECTIVE: The aim of this study was to describe an unusual phenotype in otherwise typical B-chronic lymphocytic leukemia (B-CLL) and confirm its belonging to the neoplastic cell clone. PATIENTS AND METHODS: Peripheral blood (PB) samples of 140 patients (91F/49 M, median age 61.0 years) with B-CLL were analysed by flow cytometry method (FCM). RESULTS: Immunophenotypic profile of the PB cells was consistent with the diagnosis of B-CLL: the predominancy of the CD19 and CD20 positive B-cells together with the coexpression of CD23 was found. Most of B-cells were CD5 positive with weak fluorescence of the surface immunoglobulines of mostly kappa type. After three months succesful high dose chlorambucil treatment remarkable decrease of CD8 positive B-cells (CD8+/CD19+) as well as CD5-positive B-cells (CD5+/CD20+) was observed. CONCLUSIONS: The expression of CD8 was always present on T-lymphocytes, only in one case of B-CLL aberrant and strong expression of CD8 on B-cells was found. This study shows that the expression of surface antigen CD8 on B-cells in B-CLL is a distinctly rare event and its significance still remains unknown.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0108107

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Kardum, Mirjana Mariana; Šiftar, Zoran; Nazor, Aida; Marić-Bešić, Kriskina; Radić-Krišto, Delfa; Jakšić, Branimir
B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen // Biochemia Medica, 3-4 (2002), 12; 81-85 (podatak o recenziji nije dostupan, članak, stručni)
Kardum, M., Šiftar, Z., Nazor, A., Marić-Bešić, K., Radić-Krišto, D. & Jakšić, B. (2002) B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen. Biochemia Medica, 3-4 (12), 81-85.
@article{article, year = {2002}, pages = {81-85}, keywords = {B-chronic lymphocytic leukemia, FCM, aberrant expression, CD8 antigen}, journal = {Biochemia Medica}, volume = {3-4}, number = {12}, issn = {9999-9999}, title = {B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen}, keyword = {B-chronic lymphocytic leukemia, FCM, aberrant expression, CD8 antigen} }
@article{article, year = {2002}, pages = {81-85}, keywords = {B-chronic lymphocytic leukemia, FCM, aberrant expression, CD8 antigen}, journal = {Biochemia Medica}, volume = {3-4}, number = {12}, issn = {9999-9999}, title = {B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen}, keyword = {B-chronic lymphocytic leukemia, FCM, aberrant expression, CD8 antigen} }

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