engleski

Investigation of Chromosomal Regions with Reported Linkage to Schizophrenia in a Sample with 57 Affected Sib-Pair Families from Croatia

Families having at least two siblings with schizophrenia or schizoaffective disorder (mainly schizophrenic) according to RDC were identified through the Croatian National Psychosis Register. Initially (1988), the search was for large pedigrees. As the incidence of schizophrenia had been reported in epidemiological studies to be higher in Croatia’s Istrian peninsula than the usual rate of about 1%, it seemed possible that there might be more large pedigrees than usually found elsewhere. However, later epidemiological work did not show an increase of schizophrenia in Istria, and the study therefore followed the field in adopting the affected sib-pair method. Most families in the sample came from areas surrounding Zagreb. Individuals were interviewed with SADSL, blood was drawn, and diagnosis was made by experienced clinicians (i.e. the interviewer in Croatia and one or two expert diagnosticians in New York). Fifty seven families met the criteria. Among them, 9 families had both parents available, 26 were with one parent and additional unaffected siblings, 17 without parents, but with unaffected siblings, and 4 families without parents and without additional unaffected siblings. The sample comprised 280 individuals including 137 with schizophrenia/schizoaffective disorder (2.4/family). Genotyping with microsatellite markers has been performed for candidate regions on chromosomes 1p, 4q, 5q, 6, 8p, 10p, 13q, 18, 15q, and 22q. These regions are currently evaluated using parametric and model-free methods.

chromosomal region; schizophrenia; Sib-Pair Families; Croatia

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