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Pregled bibliografske jedinice broj: 13760

Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy


Štambuk, Nikola; Brinar, Vesna; Štambuk, Vjera; Brzović, Zdravko; Zurak, Niko; Marušić-Della Marina, Branka; Karaman, Ksenija; Svoboda Beusan, Ivna; Mažuran, Renata; Rabatić, Sabina et al.
Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy // First Combined International Symposium on Ocular Immunology and Inflammation : Proceedings / Kijlstra, A. (ur.).
Amsterdam: Aeolus Press, 1998. str. S15-S15 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


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Naslov
Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy

Autori
Štambuk, Nikola ; Brinar, Vesna ; Štambuk, Vjera ; Brzović, Zdravko ; Zurak, Niko ; Marušić-Della Marina, Branka ; Karaman, Ksenija ; Svoboda Beusan, Ivna ; Mažuran, Renata ; Rabatić, Sabina ; Marotti, Tanja ; Šverko, Višnja ; Trbojević-Čepe, Milica ; Rudolf, Maja ; Martinić, Roko ; Malenica, Branko ; Sučić, Zdravko ; Gagro, Alenka ; Pokrić, Biserka

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
First Combined International Symposium on Ocular Immunology and Inflammation : Proceedings / Kijlstra, A. - Amsterdam : Aeolus Press, 1998, S15-S15

Skup
First Combined International Symposium on Ocular Immunology and Inflammation

Mjesto i datum
Amsterdam, Nizozemska, 27.06.-01.07.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
peptid-M; peptide therapy; anterior uveitis; Behçet's disease; intermediate uveitis; optic neuritis; multiple sclerosis; immunomodulation

Sažetak
Peptid-M is a small molecular mass neuropeptie (PENK, 100-104 aa), present in low quantity in different tissue including thymus. We analysed the results of peptid-M therapy in 21 patients with anterior uveitis, Behçet's disease, intermediate uveitis, optic neuritis and elapsing-remitting multiple sclerosis. Peptid-M (Lupex, Biofactor, Germany) was administered s.c. 0.25 mg/kg 5 times weekly for 4 weeks, then gradually reduced to 0.25 mg/kg weekly devided in 2 doses for >6 months. After peptide-M administration we observed marked rise in serum IFN levels, modulation of phagocite functions, NK activity, serum IL-4 and lowering of CD3+CD16+56 + cells. Clinical amelioration was noticed in all patients with uveitis and optic neuritis and in 10/12 MS patients. Improvements of VEP, colour vision, visual field abnormalities, EDSS and MRI findings were observed in most of the patients.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Farmacija

Napomena
Ocular Immunology and Inflammation (0927-3948) 6 (1998) (Suppl.)



POVEZANOST RADA


Ustanove:
Imunološki zavod d.d.,
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Štambuk, Nikola; Brinar, Vesna; Štambuk, Vjera; Brzović, Zdravko; Zurak, Niko; Marušić-Della Marina, Branka; Karaman, Ksenija; Svoboda Beusan, Ivna; Mažuran, Renata; Rabatić, Sabina et al.
Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy // First Combined International Symposium on Ocular Immunology and Inflammation : Proceedings / Kijlstra, A. (ur.).
Amsterdam: Aeolus Press, 1998. str. S15-S15 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
Štambuk, N., Brinar, V., Štambuk, V., Brzović, Z., Zurak, N., Marušić-Della Marina, B., Karaman, K., Svoboda Beusan, I., Mažuran, R. & Rabatić, S. (1998) Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy. U: Kijlstra, A. (ur.)First Combined International Symposium on Ocular Immunology and Inflammation : Proceedings.
@article{article, author = {\v{S}tambuk, Nikola and Brinar, Vesna and \v{S}tambuk, Vjera and Brzovi\'{c}, Zdravko and Zurak, Niko and Maru\v{s}i\'{c}-Della Marina, Branka and Karaman, Ksenija and Svoboda Beusan, Ivna and Ma\v{z}uran, Renata and Rabati\'{c}, Sabina and Marotti, Tanja and \v{S}verko, Vi\v{s}nja and Trbojevi\'{c}-\v{C}epe, Milica and Rudolf, Maja and Martini\'{c}, Roko and Malenica, Branko and Su\v{c}i\'{c}, Zdravko and Gagro, Alenka and Pokri\'{c}, Biserka}, editor = {Kijlstra, A.}, year = {1998}, pages = {S15-S15}, keywords = {peptid-M, peptide therapy, anterior uveitis, Beh\c{c}et's disease, intermediate uveitis, optic neuritis, multiple sclerosis, immunomodulation}, title = {Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy}, keyword = {peptid-M, peptide therapy, anterior uveitis, Beh\c{c}et's disease, intermediate uveitis, optic neuritis, multiple sclerosis, immunomodulation}, publisher = {Aeolus Press}, publisherplace = {Amsterdam, Nizozemska} }
@article{article, author = {\v{S}tambuk, Nikola and Brinar, Vesna and \v{S}tambuk, Vjera and Brzovi\'{c}, Zdravko and Zurak, Niko and Maru\v{s}i\'{c}-Della Marina, Branka and Karaman, Ksenija and Svoboda Beusan, Ivna and Ma\v{z}uran, Renata and Rabati\'{c}, Sabina and Marotti, Tanja and \v{S}verko, Vi\v{s}nja and Trbojevi\'{c}-\v{C}epe, Milica and Rudolf, Maja and Martini\'{c}, Roko and Malenica, Branko and Su\v{c}i\'{c}, Zdravko and Gagro, Alenka and Pokri\'{c}, Biserka}, editor = {Kijlstra, A.}, year = {1998}, pages = {S15-S15}, keywords = {peptid-M, peptide therapy, anterior uveitis, Beh\c{c}et's disease, intermediate uveitis, optic neuritis, multiple sclerosis, immunomodulation}, title = {Immune response and clinical findings in uveitis, optic neuritis and multiple sclerosis during Peptid-M (Lupex) therapy}, keyword = {peptid-M, peptide therapy, anterior uveitis, Beh\c{c}et's disease, intermediate uveitis, optic neuritis, multiple sclerosis, immunomodulation}, publisher = {Aeolus Press}, publisherplace = {Amsterdam, Nizozemska} }




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