Molecular defining and possible functions of Peptide-D (CROSBI ID 466540)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Štambuk, Nikola ; Pokrić, Biserka ; Vikić-Topić, Dražen ; Kazazić, Saša ; Žarković, Neven ; Garaj-Vrhovac, Vera ; Kopjar, Nevenka ; Konjevoda, Paško ; Pavan, Josip ; Marušić-Della Marina, Branka
engleski
Molecular defining and possible functions of Peptide-D
Peptide-D is a pentapeptide recently defined by N. Štambuk by means of SCA method. We investigated Peptide-D and its complementary peptide that belongs to the family of neuropeptides. The effects of the peptides on peripheral blood lymphocytes were analysed in vitro with respect to their influence on cell cycle, proliferation, apoptosis and mutagenesis. In vivo toxicity and cytoprotection were evaluated on the rat and mice model. Peptide-D and its complementary motif (transcript) were analysed by one- and two-dimensional 3H and 13C NMR spectroscopy. Their fragmentation was followed by laser description mass spectrometry. Spectroscopic findings and in vitro and in vivo studies contributed to the understanding of the physiologic and pathologic functions of the calpain-calpastatin system and possible peptid-M-FKB2 interactions. The results are discussed in the context of the several ocular diseases including cataracta, optic neuritis and uveitis and related drug design.
peptide-D; neuropeptide; SCA method; NMR; spectroscopy; cell cycle; calpain; calpastatin
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Podaci o prilogu
S15-S15.
1998.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Ocular immunology and inflammation
Kijlstra, A.
Amsterdam: Aeolus Press
0927-3948
Podaci o skupu
Combined International Symposium on Ocular Immunology and Inflammation (1 ; 1998)
poster
27.06.1998-01.07.1998
Amsterdam, Nizozemska
Povezanost rada
Kemija, Temeljne medicinske znanosti