engleski

The expression of CD44 molecule in renal cell carcinoma

It is generally accepted that the prognosis of renal cell carcinoma (RCC) differs according to the histological type, and, whatever the histological type, the tumor stage and nuclear grade are considered the main prognostic factors. However, in many cases of conventional renal cell carcinomas (CRCC), these parameters are insufficient to predict the clinical behaviour of these tumors. Therefore, several studies have focused on the evaluation of new markers. The CD44 proteins form a broadly distributed family of cell surface adhesion molecules involved in cell-cell and cell-matrix interactions. De novo expression of CD44s and its variant isoforms has been associated with aggressive behaviour in various tumours. To analyse the prognostic value of CD44s and CD44v6 in renal cell carcinomas. The expression of CD44s and CD44v6 was immunohistochemically evaluated on 75 renal cell carcinomas: 62 were CRCC, 9 papillar, 3 cromophobe and 1 collecting duct carcinoma. The expression was compared to usual clinicopathological parameters. The CD44s molecule was upregulated in 18 CRCC (29%), 4 papillary RCC, one cromophobe and one collecting duct carcinoma. Only 5 tumors were focally CD44v6 positive. The statistical analysis showed the correlation between CD44s expression and Fuhrman nuclear grade (p<0, 0025) as well as Ki67 proliferative index (p<0, 0003). The expression of CD44s molecule appears to mediate a more agressive phenotype to renal cell carcinoma.

CD44 molecule; renal cell carcinoma

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