engleski

The influence of lipoprotein lipase gene polymorphisms on coronary artery disease and plasma lipids in Zagreb cohort

We investigated the relationship between lipoprotein lipase (LPL) gene polymorphisms (-93 T/G, D9N, N291S, and S447X), coronary artery disease (CAD) and lipid traits. We examined Croatian patients with (n=497) and without (n=200) angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR: 0.36 ; p: 0.048). HLD2-cholesterol and apolipoprotein A I levels were significantly higher in non-carriers of the -93T/G and D9N polymorphisms in the CAD group (p: 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in the both groups studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p: 0.043 and 0.056, respectively). We conclude that modification in lipoprotein lipase gene might influence lipid levels, and confer risk for CAD.

lipoprotein lipase ; genetic polymorphism ; coronary artery disease

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