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Evidence based strategy for CVD prevention and treatment - an outcome study


Stavljenić Rukavina, Ana; Bernat, Robert; Šesto, Mihajlo; Ferenčak, Goran; Cheng, Suzanne
Evidence based strategy for CVD prevention and treatment - an outcome study // Clinical Chemistry and Laboratory Medicine, 41 (2003) (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)


Naslov
Evidence based strategy for CVD prevention and treatment - an outcome study

Autori
Stavljenić Rukavina, Ana ; Bernat, Robert ; Šesto, Mihajlo ; Ferenčak, Goran ; Cheng, Suzanne

Izvornik
Clinical Chemistry and Laboratory Medicine 41 (2003);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Evidence based; genetic markers; outcome

Sažetak
Over past ten years research in human genetics resulted with enormous knowledge on etiology, diagnosis and prevention of not only inherited diseases, but also of the most common diseases like diabetes and cardiovascular diseases. The lessons learned from newborn screening programs become important for developing strategy to integrate genetics into public health policies and on the broadest scale of clinical medicine. Genotypic classification of diseases might explain different outcomes and responses to therapy of individuals suffering from the same disease. Our study was undertaken with the aim to recognize genetic profile of cardiovascular disease and to investigate to what extent specific mutations or a cluster of mutations might be significant for differences in outcome of treatment. In 438 CAD patients, a set of 36 genes (74 mutations) responsible for lipoprotein metabolism, hypertension, cardiac ion channel function, endothelial cell function, glucose and homocysteine metabolism, hemostasis and coagulation were analyzed prior to angioplastic surgery. Patient group was followed up for the following three years. Survival rate and outcome were analyzed and classified according to genetic profiles and single gene mutations. The results of this study differentiated a cluster of genetic changes in CAD and recognized specific mutations connected with the outcome of treatment. The results might be important for prediction of CAD and development of additional strategy for treatment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108247

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Stavljenić Rukavina, Ana; Bernat, Robert; Šesto, Mihajlo; Ferenčak, Goran; Cheng, Suzanne
Evidence based strategy for CVD prevention and treatment - an outcome study // Clinical Chemistry and Laboratory Medicine, 41 (2003) (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)
Stavljenić Rukavina, A., Bernat, R., Šesto, M., Ferenčak, G. & Cheng, S. (2003) Evidence based strategy for CVD prevention and treatment - an outcome study. Clinical Chemistry and Laboratory Medicine, 41.
@article{article, year = {2003}, pages = {S448}, keywords = {evidence based, genetic markers, outcome}, journal = {Clinical Chemistry and Laboratory Medicine}, volume = {41}, issn = {-}, title = {Evidence based strategy for CVD prevention and treatment - an outcome study}, keyword = {evidence based, genetic markers, outcome} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI