Polymorphisms of PON1 and PON2 genes in patients with coronary artery disease (Zagreb cohort) (CROSBI ID 739452)
Prilog sa skupa u časopisu | izvorni znanstveni rad
Podaci o odgovornosti
Ferenčak, Goran ; Gršković, Branka ; Cheng, Suzanne ; Skodlar, Jasna ; Šesto, Mihajlo ; Stavljenić Rukavina, Ana
hrvatski
Polymorphisms of PON1 and PON2 genes in patients with coronary artery disease (Zagreb cohort)
Paraoxonase (PON) is a high density lipoprotein-linked enzyme which exerts its antioxidant effect by removing lipid peroxidation products. Several polymorphic loci have been identified in PON1 (M55L and R192Q) and PON2 (S311C) genes. The aim of our case-control study was to determine whether these genetic variants have an impact on the risk of developing coronary artery disease (CAD). Based on angiography results, the patients were divided into CAD (n=479) and control (n=200) groups. Genotyping was performed by multi-target PCR followed by detection of amplified alleles with linear arrays of immobilized sequence-specific probes on nylon membrane strips. All the genotypes were in Hardy-Weinberg equilibrium. Odds ratios (OR) for the genotypes were calculated by logistic regression after adjusting for age, sex, log (triglyceride), total and HDL-cholesterol, lipoprotein (a), fibrinogen, diabetes, hypertension and smoking. The MM genotype of the PON1 gene was associated with increased risk of developing CAD (OR 1.92, 95% CI 1.12-3.33, p=0.017), whereas the other two polymorphic sites did not show significant association with CAD. Multivariate analysis with age, sex, diabetes, hypertension and smoking as covariates did not show significant effect of any of the three polymorphic loci tested on serum concentrations of total, HDL-, LDL-cholesterol, triglycerides, lipoprotein (a), apolipoproteins AI, B and E. In conclusion, the MM genotype confers significant risk of developing CAD in Croatian population.
paraoxonase; coronary artery disease; gene polymorphism
nije evidentirano
engleski
Polymorphisms of PON1 and PON2 genes in patients with coronary artery disease (Zagreb cohort)
nije evidentirano
paraoxonase; coronary artery disease; gene polymorphism
nije evidentirano
Podaci o prilogu
S322-x.
2003.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Clinical chemistry and laboratory medicine
1434-6621
1437-4331
Podaci o skupu
Nepoznat skup
ostalo
29.02.1904-29.02.2096
Povezanost rada
Temeljne medicinske znanosti