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Pregled bibliografske jedinice broj: 135472

The role of mismatch repair in bacterial evolution


Džidić, Senka; Bačun-Družina, Višnja; Petranović, Mirjana
The role of mismatch repair in bacterial evolution // Food Technology and Biotechnology, 41 (2003), 2; 177-182 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
The role of mismatch repair in bacterial evolution

Autori
Džidić, Senka ; Bačun-Družina, Višnja ; Petranović, Mirjana

Izvornik
Food Technology and Biotechnology (1330-9862) 41 (2003), 2; 177-182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
mismatch repair system; mutator bacteria; adaptive mutagenesis; evolution

Sažetak
Experimental (directed) evolution is a study of evolution under defined and reproducible conditions, particularly on model laboratory populations of bacteria. Recently, remarkable success of directed evolution has been reported, ranging from industrial enzymes, with substantially improved activities and thermostabilities, to vaccines and pharmaceuticals as well as generation of novel microorganisms with desired properties. It has become clear that the major process influencing evolution is DNA mismatch repair (MMR). The MMR system controls genome stability of the species and is highly conserved from bacteria to humans. It maintains the integrity of DNA by repairing errors made during the replication process and by preventing genetic recombination between diverged DNAs. Inactivation of MMR results in the generation of hereditary mutators with highly increased mutation rates as well as in abolishment of genetic barriers between species. Most of the mutations are deleterious, but some of them are beneficial and enable mutators to survive environmental stress. In the stable environment mutators lose their advantage because of accumulating deleterious mutations. Strains with beneficial mutations could survive by reacquiring MMR wild type alleles in horizontal gene transfer through hyperrecombination phenotype of MMR mutators. During evolutionary history, MMR functions have been repeatedly lost and reacquired by horizontal gene transfer, which gives rise to the mosaic gene structure of MMR genes. This mosaicism is a hallmark of the evolutionary process.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija



POVEZANOST RADA


Projekti:
0098071
0058013

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb


Citiraj ovu publikaciju

Džidić, Senka; Bačun-Družina, Višnja; Petranović, Mirjana
The role of mismatch repair in bacterial evolution // Food Technology and Biotechnology, 41 (2003), 2; 177-182 (međunarodna recenzija, pregledni rad, znanstveni)
Džidić, S., Bačun-Družina, V. & Petranović, M. (2003) The role of mismatch repair in bacterial evolution. Food Technology and Biotechnology, 41 (2), 177-182.
@article{article, year = {2003}, pages = {177-182}, keywords = {mismatch repair system, mutator bacteria, adaptive mutagenesis, evolution}, journal = {Food Technology and Biotechnology}, volume = {41}, number = {2}, issn = {1330-9862}, title = {The role of mismatch repair in bacterial evolution}, keyword = {mismatch repair system, mutator bacteria, adaptive mutagenesis, evolution} }
@article{article, year = {2003}, pages = {177-182}, keywords = {mismatch repair system, mutator bacteria, adaptive mutagenesis, evolution}, journal = {Food Technology and Biotechnology}, volume = {41}, number = {2}, issn = {1330-9862}, title = {The role of mismatch repair in bacterial evolution}, keyword = {mismatch repair system, mutator bacteria, adaptive mutagenesis, evolution} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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