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Pregled bibliografske jedinice broj: 135073

Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells


Markotić, Alemka; Hensley, L; Gisbert, T; Spik, K; Schnaljohn, C
Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells // Journal of General Virology, 84 (2003), 2197-2202 (međunarodna recenzija, članak, znanstveni)


Naslov
Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells

Autori
Markotić, Alemka ; Hensley, L ; Gisbert, T ; Spik, K ; Schnaljohn, C

Izvornik
Journal of General Virology (0022-1317) 84 (2003); 2197-2202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hantavirus; cytopathogenic effect; human cell line; apoptosis
(Hantavirus; citopatogeni učinak; humana stanična linija; apoptoza)

Sažetak
Hantaviruses are maintained in nature in persistently infected rodents and can also persistently infect cultured mammalian cells, causing little or no cytopathology. An unexpected outcome of this study was the observation of cytopathic effects (CPE) in the hantavirus-infected human embryonic kidney cell line HEK293. It was confirmed that hantaviruses induce apoptosis in HEK293 cells, although apoptosis appeared mostly in uninfected, bystander cells and rarely in infected HEK293 cells. Although studies by others suggest that the nucleocapsid protein of Puumala virus interacts with the Fas-mediated apoptosis enhancer Daxx at the gene expression level, it was determined that members of the TNF receptor superfamily did not contribute to the apoptosis observed in infected HEK293 cells. The observation of CPE in HEK293 cells might lead to a better understanding of the mechanisms of persistence and pathogenesis in hantavirus infections.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0021005

Ustanove
Imunološki zavod d.d.

Autor s matičnim brojem:
Alemka Markotić, (213111)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE