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Pregled bibliografske jedinice broj: 135015

Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed


Baričević, Marijana; Forčić, Dubravko; Košutić Gulija, Tanja; Zgorelec, Renata; Mažuran, Renata
Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed // 12th International Conference on Negative Strand Viruses 2003 / Brian, WJ, Mahy ; Dan, Kolakofsky ; Mauro, Bendinelli (ur.).
Pisa, 2003. str. 326-326 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed

Autori
Baričević, Marijana ; Forčić, Dubravko ; Košutić Gulija, Tanja ; Zgorelec, Renata ; Mažuran, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
12th International Conference on Negative Strand Viruses 2003 / Brian, WJ, Mahy ; Dan, Kolakofsky ; Mauro, Bendinelli - Pisa, 2003, 326-326

Skup
12th International Conference on Negative Strand Viruses

Mjesto i datum
Piza, Italija, 14-19.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
measles vaccine; Edmonston-Zagreb; sequences

Sažetak
Edmonston-Zagreb vaccine strain is derived from a single clinical isolate of measles virus called the Edmonston strain and used for production of measles vaccine. Protein coding and noncoding sequences of the original Edmonston-Zagreb master seed, manufactured in 1967, and working seed D_24 2/99 lot, manufactured in 1999, were determined directly from DNA fragments generated by RT-PCR and sequenced by automated sequence apparatus. The coding and noncoding sequences of the Edmonston-Zagreb master seed and the working seed D_24 2/99 do not differ. The sequences are compared to reference strains, i.e. Edmonston wild type AF266288 and Edmonston Zagreb AF266290 (Parks et al., J. Virol. 75: 910-920, 2001). Differences were found in at least 29 and 6 nucleotide positions respectively. We suppose that such a substantial number of observed differences could be due to additional four passages of Edmonston-Zagreb AF266290 in Vero cell culture (Parks et al., J. Virol. 75: 910-920, 2001).

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

Napomena
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POVEZANOST RADA


Projekti:
0021001

Ustanove:
Imunološki zavod d.d.


Citiraj ovu publikaciju:

Baričević, Marijana; Forčić, Dubravko; Košutić Gulija, Tanja; Zgorelec, Renata; Mažuran, Renata
Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed // 12th International Conference on Negative Strand Viruses 2003 / Brian, WJ, Mahy ; Dan, Kolakofsky ; Mauro, Bendinelli (ur.).
Pisa, 2003. str. 326-326 (poster, međunarodna recenzija, sažetak, znanstveni)
Baričević, M., Forčić, D., Košutić Gulija, T., Zgorelec, R. & Mažuran, R. (2003) Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed. U: Brian, WJ, Mahy, Dan, K. & Mauro, B. (ur.)12th International Conference on Negative Strand Viruses 2003.
@article{article, year = {2003}, pages = {326-326}, keywords = {measles vaccine, Edmonston-Zagreb, sequences}, title = {Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed}, keyword = {measles vaccine, Edmonston-Zagreb, sequences}, publisherplace = {Piza, Italija} }
@article{article, year = {2003}, pages = {326-326}, keywords = {measles vaccine, Edmonston-Zagreb, sequences}, title = {Determination of the coding and noncoding nucleotide sequences of original Edmonston-Zagreb master seed and current working seed}, keyword = {measles vaccine, Edmonston-Zagreb, sequences}, publisherplace = {Piza, Italija} }




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