engleski

Association study of candidate genes in Croatian myocardial infarction patients

Association of 65 biallelic polymorphisms or mutations within 36 genes, selected from pathways of lipid and homocysteine metabolism, regulation of blood pressure and coagulation, inflammation, cellular adhesion, and matrix integrity, with myocardial infarction was investigated in a case-control study. Multiplex assay genotyping was done in 257 subjects with a history of myocardial infarction (MI+) and 490 control subjects (MI-). The analyzed genes were LPA, APOA4, APOB, APOC3, APOE, ADRB3, PPARG, LIPC, LPL, PON1, PON2, LDLR, CETP, CBS, MTHFR, NOS3, DCP1, AGTR1, AGT, NPPA, ADD1, SCNN1A, GNB3, ADRB2, MMP3, F2, F5, F7, PAI1, FGB, ITGA2, ITGB3, SELE, ICAM1, TNF, and LTA. After adjusting for age, sex, smoking, hypertension, plasma homocysteine, lipids and glucose, we found an association (P less than or equal to 0.05) of polymorphisms in ADRB3 (OR 1.649, 95% CI 1.063-2.558), PPARG (OR 0.530, 95% CI 0.371-0.756), AGTR1 (OR 1.824, 95% CI 1.306-2.547), NPPA (OR 2.344, 95% CI 1.108-4.961), and FGB genes (OR 2.167, 95% CI 1.044-4.499) with myocardial infarction. The results are strongly supporting the hypothesis of the polygenic inheritance of susceptibility to myocardial infarction as a result of an interaction between various metabolic pathways involved in the pathogenesis of atherosclerosis.

gene polymorphism; myocardial infarction

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