engleski

Lipoprotein lipase gene polymorphisms in Croatian patients with coronary artery disease

Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced HDL, both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S and S447X polymorphisms in the LPL gene on CAD risk and lipid levels in Croatian patients with and without angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR: 0.36 ; 95% CI: 0.13, 0.99 ; p: 0.048). This association was only moderately effected by adjusting for various lipids (OR: 0.36 ; 95% CI: 0.12, 1.08 ; p: 0.068). HLD2- cholesterol and apolipoprotein A I levels were significantly higher in non-carriers of the -93T/G and D9N polymorphisms in the CAD group (p: 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in the both groups studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p: 0.043 and 0.056, respectively). LPL gene polymorphisms might be involved in predisposition to CAD and determination of lipid profiles.

coronary artery disease ; genetic polymorphism ; lipoprotein lipase ; lipids

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