engleski

Antioxidative vitamin substitution in traumatic shock

Traumatic shock as an acute and general disorder in perfusion of all organ systems is related to oxidant /antioxidant imbalance. Vitamin E is the most effective lipid soluble antioxidant. The aim of this work was to investigate the level in which the use of antioxidative vitamins E and C decreased adverse effects of lipid peroxidation in traumatic shock. For this purpose, two groups of patients with traumatic shock aged 20-45 years were tested: 1) 10 patients administered the substitution of vitamin E (300 mg) and of C (1000 mg ) during the first 7 days after admission ; 2) 10 patients without substitution. The study was performed during four different periods: at admission, on day 3, on day 7, and on day 15 after admission. Vitamin E was determined by HPLC method using fluorescent detector. Vitamin E values were as follows: 1) 5.9, 5.6, 5.8, 8.6 ng/ml in group with substitution, 2) 5.7, 5.2, 4.7, 6.6 ng/ml in group without substitution. Vitamin E concentration was on day 15 increased by 30% in the group administered vitamin E and vitamin C, thus suggesting that vitamin E and vitamin C substitution might be justified in patients with traumatic shock.

vitamin substitution; traumatic shock

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