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Pregled bibliografske jedinice broj: 134254

Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease


Ferenčak, Goran; Lovrić, Mila; Gršković, Branka; Šesto, Mihajlo; Cheng, Suzanne; Skodlar, Jasna; Fijal, Bonnie; Stavljenić Rukavina, Ana
Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease // Clinical Chemistry & Laboratory Medicine, 40 (2002) (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)


CROSBI ID: 134254 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease

Autori
Ferenčak, Goran ; Lovrić, Mila ; Gršković, Branka ; Šesto, Mihajlo ; Cheng, Suzanne ; Skodlar, Jasna ; Fijal, Bonnie ; Stavljenić Rukavina, Ana

Izvornik
Clinical Chemistry & Laboratory Medicine 40 (2002);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
coronary artery disease; MTHFR; CBS

Sažetak
Hyperhomocysteinemia is a risk factor for cardiovascular disease. Total plasma homocysteine (tHcy) is influenced by nutritional and genetic factors. The prevalence of common mutations, C677T in methylenetetrahydrofolate reductase (MTHFR) and 844 ins 68 in cystathionine beta-synthase gene (CBS) have been studied in 528 patients with angiographically confirmed coronary artery disease (CAD) and in 219 healthy age and sex matched control subjects. Severity of disease was expressed as number of affected vessels. tHcy was measured by FPIA. There was no significant difference in genotype distributions of the MTHFR and CBS genes between groups (p=0.08 and 0.31, respectively). However, patients with CT or TT genotype in MTHFR had significantly higher tHcy levels (p=0.009). Also, groups with 0, 1, 2 and 3 or more affected vessels differed in tHcy levels (ANOVA, p<0.001). In conclusion, MTHFR and CBS mutations are not independent risk factors for CAD, but C677T mutation influences tHcy levels.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0108247

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Ferenčak, Goran; Lovrić, Mila; Gršković, Branka; Šesto, Mihajlo; Cheng, Suzanne; Skodlar, Jasna; Fijal, Bonnie; Stavljenić Rukavina, Ana
Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease // Clinical Chemistry & Laboratory Medicine, 40 (2002) (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)
Ferenčak, G., Lovrić, M., Gršković, B., Šesto, M., Cheng, S., Skodlar, J., Fijal, B. & Stavljenić Rukavina, A. (2002) Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease. Clinical Chemistry & Laboratory Medicine, 40.
@article{article, year = {2002}, pages = {S118}, keywords = {coronary artery disease, MTHFR, CBS}, journal = {Clinical Chemistry and Laboratory Medicine}, volume = {40}, issn = {-}, title = {Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease}, keyword = {coronary artery disease, MTHFR, CBS} }
@article{article, year = {2002}, pages = {S118}, keywords = {coronary artery disease, MTHFR, CBS}, journal = {Clinical Chemistry and Laboratory Medicine}, volume = {40}, issn = {-}, title = {Common methylenetetrahidrofolate reductase and cystathionine-beta-synthase mutations and homocysteine levels in patients with coronary artery disease}, keyword = {coronary artery disease, MTHFR, CBS} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI





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