Spectrophotometric determination of dissociation constants of the two oxime groups of 1, 1'-bis(pyridinium-4-aldoxime)trimethylene dibromide (CROSBI ID 493760)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Foretić, Blaženka ; Burger, Nicoletta
engleski
Spectrophotometric determination of dissociation constants of the two oxime groups of 1, 1'-bis(pyridinium-4-aldoxime)trimethylene dibromide
The dissociation constants of the two oxime groups of 1, 1&#8217 ; ; -bis(pyridinium-4-aldoxime)trimethylene dibromide (TMB-4), a potent reactivator of the acetylcholinesterase inhibited by organophoshorus poisons, were determined from spectrophotometric data. Two numerical methods were used to treat the existing overlapping equilibria. The obtained results were in good agreement and their mean values at 25 oC corrected for the ionic strength of 0.05 M are pKa1 = 7.49 and pKa2 = 8.96. These values are discussed in terms of the pKas of 1, 1&#8217 ; ; -bis(pyridinium 4-aldoxime)oxydimethylene dichloride (Toxogonin), a similar dioxime, also known as an acetylcholinesterase reactivator, which were derived by extrapolation of literature data.
1; 1’; -Bis(pyridinium-4-aldoxime)trimethylene dibromide; Dissociation constants; Spectrophotometry
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Podaci o prilogu
108-108-x.
2003.
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts: 10th European Conference on the Spectroscopy of Biological Molecules
Szalontai B., Kota Z.
Segedin: Institute of Biophysics Biological Research Centre, Hungarian Academy of Scinces
Podaci o skupu
10th European Conference on the Spectroscopy of Biological Molecules
poster
30.08.2003-04.09.2003
Szeged, Mađarska