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Pregled bibliografske jedinice broj: 133314

The role of NKG2D co-stimulation in MCMV control by CD8+ T lymphocytes


Hasan, Milena; Bubić, Ivan; Krmpotić, Astrid; Yokoyama, Wayne; Jonjić, Stipan
The role of NKG2D co-stimulation in MCMV control by CD8+ T lymphocytes // 9th International Cytomegalovirus Workshop, Maastricht, Netherlands / Vink, Kees ; Bruggeman, Cathrien (ur.).
Maastricht, 2003. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
The role of NKG2D co-stimulation in MCMV control by CD8+ T lymphocytes

Autori
Hasan, Milena ; Bubić, Ivan ; Krmpotić, Astrid ; Yokoyama, Wayne ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th International Cytomegalovirus Workshop, Maastricht, Netherlands / Vink, Kees ; Bruggeman, Cathrien - Maastricht, 2003

Skup
9th International Cytomegalovirus Workshop

Mjesto i datum
Maastricht, Netherlands, 20-25.05.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NKG2D; MCMV; m152; CD8 T lymphocytes

Sažetak
NKG2D is an activating NK cell receptor, expressed also by activated macrophages and CD8+ T lymphocytes. At the surface of CD8+ T cells NKG2D serves as a co-stimulatory receptor. We have recently shown that gp40, encoded by m152 MCMV gene, down-regulates cellular ligands for NKG2D receptor, thereby inhibiting NK cell activation and promoting virus growth in vivo (Krmpotic et al., MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo, Nat Immunol 3:529, 2002.). In this work we investigated the significance of NKG2D co-stimulation for CD8+ T cell-mediated control of MCMV infection in vivo. To this end NKG2D receptors on CD8+ T lymphocytes were blocked by an anti-NKG2D antibody and the cells were tested for their antiviral activity after adoptive transfer into MCMV infected syngeneic recipients. To assess the role of m152/gp40-mediated down-regulation of NKG2D ligands in CD8+ T cell-mediated virus control, the same protocol was performed for m152 deletion mutant and its revertant virus strain. Our preliminary results support the notion about the importance of NKG2D co-stimulation for virus control by CD8+ T cell in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0062004
0062007

Ustanove
Medicinski fakultet, Rijeka

Profili:

Avatar Url Milena Hasan (autor)

Avatar Url Astrid Krmpotić (autor)

Avatar Url Ivan Bubić (autor)

Avatar Url Stipan Jonjić (autor)

Citiraj ovu publikaciju

Hasan, Milena; Bubić, Ivan; Krmpotić, Astrid; Yokoyama, Wayne; Jonjić, Stipan
The role of NKG2D co-stimulation in MCMV control by CD8+ T lymphocytes // 9th International Cytomegalovirus Workshop, Maastricht, Netherlands / Vink, Kees ; Bruggeman, Cathrien (ur.).
Maastricht, 2003. (poster, međunarodna recenzija, sažetak, znanstveni)
Hasan, M., Bubić, I., Krmpotić, A., Yokoyama, W. & Jonjić, S. (2003) The role of NKG2D co-stimulation in MCMV control by CD8+ T lymphocytes. U: Vink, K. & Bruggeman, C. (ur.)9th International Cytomegalovirus Workshop, Maastricht, Netherlands.
@article{article, year = {2003}, pages = {69}, keywords = {NKG2D, MCMV, m152, CD8 T lymphocytes}, title = {The role of NKG2D co-stimulation in MCMV control by CD8 and \#43; T lymphocytes}, keyword = {NKG2D, MCMV, m152, CD8 T lymphocytes}, publisherplace = {Maastricht, Netherlands} }