Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

HLA class I and class II polymorphism in Croatian patients with psoriatic arthritis (CROSBI ID 739428)

Prilog sa skupa u časopisu | izvorni znanstveni rad

Grubic, Zorana ; Perić, Porin ; Čečuk-Jeličić, Esma ; Brkljačić-Kerhin, Vesna ; Ćurković, Božidar ; Kaštelan, Andrija HLA class I and class II polymorphism in Croatian patients with psoriatic arthritis // Annals of rheumatic diseases. 2002. str. 352-x

Podaci o odgovornosti

Grubic, Zorana ; Perić, Porin ; Čečuk-Jeličić, Esma ; Brkljačić-Kerhin, Vesna ; Ćurković, Božidar ; Kaštelan, Andrija

engleski

HLA class I and class II polymorphism in Croatian patients with psoriatic arthritis

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis which is caused by a combination of genetic and environmental factors. The identification of genetic markers for PsA would be of great benefit for diagnosis. The aim of this study was to investigate contribution of HLA-A, -B, -Cw and -DRB1 alleles in the susceptibility to PsA. Fifty-five unrelated patients with PsA (30 women and 25 men, mean age 46 years) were analysed. DNA was isolated by standard salting out protocol, while HLA typing was performed by Polymerase Chain Reaction -Sequence Specific Primers (PCR-SSP) method. The results were compared with a sample of 141 healthy unrelated individuals using Chi-square test with Yates correction and the Fischer's exact test. The relative risk for estimating the strenght of association of the disese with a given allele was calculated by means of Woolf's method. Our results showed that none of 15 distinct HLA-A alleles was increased or decreased in the PsA group, while among 19 different alleles at HLA-B locus 3 alleles showed statistically significant differences between two tested groups. Allele B*13 (7.3% vs 2.6%, p=0.023), B*39 (14.5% vs 2.4%, p=0.0001) and B*27 (15.5% vs 5.0%, p=0.0003) were increased. At HLA-Cw locus, twenty-two patients were Cw*07 (40.4% vs 18.1%, p=0.002) and thirteen patients were positive for Cw*0602 allele (23.1% vs 9.7%, p=0.02). Among HLA-DRB1 alleles, DRB1*0701 showed significant increase in patients with PsA (15.7% vs 7.8%, p=0.019). Results indicated that the higest relative risk (RR) was observed for B*39 (RR=6.19) followed by B*27 (RR=4.25), B*13 (RR=3.40), Cw*07 (RR=3.07), Cw*0602 (RR=2.93) and DRB1*0701 (RR=2.68). The data obtained in this study are consistent with the polygenic inheritance of PsA. Allele B*39 appears to be the strongest genetic susceptibility factor for disease. Further study with larger number of PsA patients is necessary to confirm these findings and to elucidate a possible role of non- HLA loci in the region between HLA B and Cw loci in the susceptibility to PsA.

psoriatic arthritis; HLA class I and class II

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

352-x.

2002.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Annals of rheumatic diseases

0003-4967

Podaci o skupu

Nepoznat skup

ostalo

29.02.1904-29.02.2096

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost