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The MCMV m152/gp40 glycoprotein achieves simulateous avoidance of CD8+ and NK cell-mediated immune control


Krmpotić, Astrid; Bubić, Ivan; Hengel, Hartmut; Scalzo, Anthony; Koszinowski, Ulrich; Jonjić Stipan
The MCMV m152/gp40 glycoprotein achieves simulateous avoidance of CD8+ and NK cell-mediated immune control // 8th International Cytomegalovirus Conference, Monterey, California / Mocarski, Ed ; Drew, Lawrence (ur.).
Monterey, 2001. (predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
The MCMV m152/gp40 glycoprotein achieves simulateous avoidance of CD8+ and NK cell-mediated immune control

Autori
Krmpotić, Astrid ; Bubić, Ivan ; Hengel, Hartmut ; Scalzo, Anthony ; Koszinowski, Ulrich ; Jonjić Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
8th International Cytomegalovirus Conference, Monterey, California / Mocarski, Ed ; Drew, Lawrence - Monterey, 2001

Skup
8th International Cytomegalovirus Conference

Mjesto i datum
Monterey, California, 20-25.05.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; NK cells; m152; immunevasion

Sažetak
The MCMV glycoprotein gp40, encoded by the m152 gene retains MHC class-I complexes in the ERGIC/cis-Golgi compartment, allowing the virus to evade control by CD8 positive T lymphocytes in vivo. Since cell surface class-I molecules interact with inhibitory receptors to avoid NK cell attack, down-modulation of MHC-I molecules may increase MCMV susceptibility to NK cells. However, we found that gp40 severely inhibits NK cell-mediated virus control in vivo. This effect is mouse strain dependent but independent of Cmv1, a locus which restricts early MCMV replication in the spleen through the action of NK cells. In mouse strains sensitive to the gp40-medaited effect (e.g. BALB/c) the NK cell response is strongly attenuated by the expression of m152, while in resistant strains (e.g. B6) replication of both, the m152 deletion mutant and the m152 revertant virus is efficiently controlled by NK cells. Transfer studies of MCMV infected cells from resistant into sensitive strains reviled that both NK receptors as well as ligands present on NK stimulator cells determine the m152/gp40 phenotype. Taking advantage of intra-natural killer complex (NKC) recombinant BALB/c/B6 and congenic mouse strains we are currently mapping loci encompassing gp40-sensitive NK cell receptor(s) on mouse chromosome 6.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0062004
0062007

Profili:

Avatar Url Astrid Krmpotić (autor)

Avatar Url Ivan Bubić (autor)

Avatar Url Stipan Jonjić (autor)

Citiraj ovu publikaciju

Krmpotić, Astrid; Bubić, Ivan; Hengel, Hartmut; Scalzo, Anthony; Koszinowski, Ulrich; Jonjić Stipan
The MCMV m152/gp40 glycoprotein achieves simulateous avoidance of CD8+ and NK cell-mediated immune control // 8th International Cytomegalovirus Conference, Monterey, California / Mocarski, Ed ; Drew, Lawrence (ur.).
Monterey, 2001. (predavanje, međunarodna recenzija, sažetak, znanstveni)
Krmpotić, A., Bubić, I., Hengel, H., Scalzo, A., Koszinowski, U. & Jonjić Stipan (2001) The MCMV m152/gp40 glycoprotein achieves simulateous avoidance of CD8+ and NK cell-mediated immune control. U: Mocarski, E. & Drew, L. (ur.)8th International Cytomegalovirus Conference, Monterey, California.
@article{article, year = {2001}, pages = {57}, keywords = {MCMV, NK cells, m152, immunevasion}, title = {The MCMV m152/gp40 glycoprotein achieves simulateous avoidance of CD8+ and NK cell-mediated immune control}, keyword = {MCMV, NK cells, m152, immunevasion}, publisherplace = {Monterey, California} }