Platelet 5-HT concentrations and suicidal behaviour in reccurent major depression (CROSBI ID 77334)
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Podaci o odgovornosti
Muck-Šeler, Dorotea ; Jakovljević, Miro ; Pivac, Nela
engleski
Platelet 5-HT concentrations and suicidal behaviour in reccurent major depression
Platelet 5-HT concentrations were determined in 84 male and 82 female psychotic and non-psychotic depressed inpatients with various degrees of suicidal behaviour, and in 175 healthy controls. Psychotic patients had higher platelet 5-HT concentrations than non-psychotic depressed patients and healthy controls. A sex difference, i.e. lower platelet 5-HT concentrations in females was found in healthy controls, depressed patients, non-psychotic patients and non-suicidal depressed patients. A negative relationship was shown between platelet 5-HT concantrations and suicidal behaviour. The lowest platelet 5-HT concentrations were associated with the most pronounced suicidal behaviour (with suicidal attempts and with the acts of suicide). The results suggest that the differences in platelet 5-HT concentrations found in depressed patients might be used as a biological marker for suicidal behaviour.
Platelet 5-HT ; recurrent major depression ; suicidality ; sex difference ; psychotic and nonpsychotic patient
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Podaci o izdanju
39 (1)
1996.
73-80
objavljeno
0165-0327
1573-2517
10.1016/0165-0327(96)00024-9
Povezanost rada
Temeljne medicinske znanosti