engleski

Antioxidant defense in bypass patients

Twenty-nine patients who underwent surgical bypass were included in our research. Conventional myocardial revascularization was performed with CPB support on 11 patients and the other 18 was not. Samples were collected before surgery and 1.5 ; 6 ; 24 and 72 hours after the operation. Changes of the antioxidative parameters were monitored in the: whole blood - GPX, erythrocytes - SOD, leukocytes (TAS), and sera (TAS). Activity of SOD in RBC was significantly increased during entire postoperative period (11-14%) while, GPX activity after the surgery was not statistically significantly increased in relation to preoperative values. TAS concetration in sera was decreased during entire postoperative period, but TAS in both lysates is higher mainly first few hours after the operation. Intensity of the changes in all determined parameters does not differ whether cardiopulmonary bypass (CPB) support was used or not.

bypass; oxidative stress; superoxide dismutase; glutathione peroxidase; total antioxidant status

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