Regional differences in NaCl-induced increase of the potency of bicuculline to displace (3H)/muscimol binding (CROSBI ID 77328)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Bujas, Maja ; Tvrdeić, Ante ; Peričić, Danka
engleski
Regional differences in NaCl-induced increase of the potency of bicuculline to displace (3H)/muscimol binding
It has been shown that the potency of bicuculline to displace [H-3]muscimol binding to crude brain membranes can be enhanced markedly by different anions. This study shows that although bicuculline alone was a more potent displacer of [H-3]muscimol binding in cortical than in cerebellar membranes, the NaCl (250 mM)-induced leftward shift of the bicuculline inhibition curve of [H-3]muscimol binding was considerably higher in cerebellum than in cortex. The same concentration of NaCl failed to affect either the affinity or the density of cortical and cerebellar [H-3]muscimol binding sites. The results suggest that sodium chloride is able to reveal regional differences in bicuculline potency.
(3H)muscimol binding; regional differences; bicuculline; NaCl
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Podaci o izdanju
30 (2)
1997.
199-202
objavljeno
0197-0186
10.1016/S0197-0186(96)00054-X
Povezanost rada
Temeljne medicinske znanosti