engleski

Stochastic Simulation of a Single Gene Cell Model

Proposed is a generic single gene cell model as an extension of a &#8220 ; standard&#8221 ; single enzyme (Monod) model. The model is structured at three levels: 1) gene transcription, 2) enzyme synthesis, 3) metabolite and protein production. It accounts for a limiting substrate consumption, metabolite and biomass component production, gene transcription and enzyme synthesis. Assumed are control interactions between the key components at each level based on catalytic effects. Simulated is induction of gene transcription and enzyme synthesis as a cell response to step change of extracellular medium composition. In view of small number of key molecules stochastic simulation is applied.

Cell model; stochastic simulation; metabolic control

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