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Pregled bibliografske jedinice broj: 128730

The ability of fungal isolates from human lung aspergilloma to produce mycotoxins


Pepeljnjak, Stjepan; Slobodnjak, Zoran; Šegvić, Maja; Peraica, Maja; Pavlović, Mladen
The ability of fungal isolates from human lung aspergilloma to produce mycotoxins // Human and experimental toxicology, 23 (2004), 1; 15-19 (međunarodna recenzija, članak, znanstveni)


Naslov
The ability of fungal isolates from human lung aspergilloma to produce mycotoxins

Autori
Pepeljnjak, Stjepan ; Slobodnjak, Zoran ; Šegvić, Maja ; Peraica, Maja ; Pavlović, Mladen

Izvornik
Human and experimental toxicology (0960-3271) 23 (2004), 1; 15-19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Aspergillus fumigatus; Aspergillus versicolor; lung; Aspergilloma; aflatoxins; sterigmatocystin

Sažetak
This study included 11 adult patients (7 men and 4 women) who had been surgically treated for pulmonary aspergilloma in the Republic of Croatia within two years. Mycologic analysis was positive for Aspergillus genus in five samples of surgically removed tissue. A. fumigatus was isolated in three and A. versicolor in two samples. A. fumigatus strains were found to produce aflatoxin B1 (AFB1) in the range of 0.025-0.145 mg/ml biomass, and two of them aflatoxin G1 in concentrations of 0.033 and 0.042 mg/ml. A. versicolor strains produced AFB1 (0.035 and 0.094 mg/ml) and sterigmatocystin (0.50 and 6.67 mg/ml). Neither of isolated Aspergillus strain produced aflatoxin G2 or ochratoxin A. Fungal growth and production of mycotoxins is the consequence of interaction of fungus, host and environment. Although the production of mycotoxins in vitro does not necessarily reflect what these fungi may produce in human organism, the toxigenicity of examined strains suggests that patients with the pulmonary aspergilloma could be chronically exposed to mycotoxins.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
0006641
0022006
0022018

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Biological Abstracts
  • Chemical Abstracts