engleski

Precise Annotation of Transmembrane Segments with Garlic - Free Molecular Visualization Program

The comparison of transmembrane secondary structure prediction programs requires precise annotations of transmembrane segments of known proteins. The annotations which may be found in different databases differ significantly due to the lack of standard method for annotation of transmembrane segments. Simple methods for the placement of bilayer membrane with respect to the known 3D structure of membrane protein were developed to improve the precise determination of transmembrane portion of the protein. The methods were implemented in freely available, open source molecular visualization program called garlic. The program, complete with the source code and extensive documentation, may be found at the site: http://garlic.mefos.hr/garlic

membrane proteins; transmembrane part; molecular visualization; membrane model; hydrophobicity

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