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Genetic assessment and treatment decision-making in patients with metastatic breast cancer in University Hospital Center Zagreb

Metastatic breast cancer is an incurable disease with highly variable clinical course and outcome. Intrinsic genetic heterogeneity of the primary breast tumor may play a role in this variability and may explain it in part. The aim of the study was to determine pathogenic and likely pathogenic variants in a set of highly penetrance genes which can provide new information in the process of treatment decisionmaking. There is still an insufficient number of metastatic patients in our genetic assessment group because of limited resources. Nevertheless, multi-gene testing provided a substantial benefit in clinical management of breast cancer because the small subset of patients were found suitable for the PARP-inhibitor therapy.

Metastatic breast cancer, genetic assessment, treatment

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