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Clozapine-Induced Inflammation: What Psychiatrists Should Know?

Clozapine continues to stand out as the most effective drug in the treatment of schizophrenia. It remains the only drug approved for the treatment-resistant schizophrenia, which, unfortunately, affects up to a quarter of people even in the early stages of this disorder (Siskind et al. 2022), and also the only antipsychotic with antisuicidal effects (Forte et al. 2021). At the same time, clozapine has a number of safety considerations, which contribute to its substantial underutilization (Gurrera et al. 2022).

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