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Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study (CROSBI ID 325413)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Dobrović, Karolina ; Škrobo, Tea ; Selec, Katarina ; Jelić, Marko ; Čivljak, Rok ; Peršec, Jasminka ; Sakan, Sanja ; Bušić, Nikolina ; Mihelčić, Antonija ; Hleb, Sonja et al. Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study // Microorganisms, 11 (2023), 3; 774-13. doi: 10.3390/microorganisms11030774

Podaci o odgovornosti

Dobrović, Karolina ; Škrobo, Tea ; Selec, Katarina ; Jelić, Marko ; Čivljak, Rok ; Peršec, Jasminka ; Sakan, Sanja ; Bušić, Nikolina ; Mihelčić, Antonija ; Hleb, Sonja ; Tambić Andrašević, Arjana

engleski

Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study

Abstract: Healthcare-associated infections have been an emerging cause of morbidity and mortality in COVID-19 intensive care units (ICUs) worldwide, especially those caused by multi-drug resistant (MDR) pathogens. The objectives of this study were to assess the incidence of bloodstream infections (BSIs) among critically ill COVID-19 patients and to analyze characteristics of healthcare- associated BSIs due to MDR Acinetobacter baumannii in a COVID-19 ICUs. A single center retrospective study was conducted at a tertiary care hospital during a 5-months period. Detection of carbapenemase genes was performed by PCR while genetic relatedness by pulsed-field gel electrophoresis (PFGE) and multilocus-sequence typing (MLST). A total of 193 episodes of BSIs were registered in 176 COVID-19 ICU patients, with incidence of 25/1000 patient-days at risk. A. baumannii was the most common etiological agent (40.3%) with resistance to carbapenems of 100%. The blaOXA-23 gene was detected in ST2 isolates while blaOXA-24 gene was ST636 specific. PFGE analysis revealed homogeneous genetic background of the isolates. Clonal spread of OXA-23 positive A. baumannii is responsible for high prevalence of MDR A. baumannii BSIs in our COVID-19 ICUs. Further surveillance of resistance trends and mechanisms are needed along with behavior change towards better implementation of infection control and rational use of antibiotics.

Acinetobacter baumannii ; blaOXA-23 ; bloodstream infection ; carbapenemase genes ; carbapenem re-sistance ; COVID-19 ; healthcare-associated infections ; intensive care units ; multidrug-resistant

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Podaci o izdanju

11 (3)

2023.

774-13

objavljeno

2076-2607

10.3390/microorganisms11030774

Povezanost rada

Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Kliničke medicinske znanosti

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