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Stress and the endocrine system (CROSBI ID 735887)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija

Baretić, Maja Stress and the endocrine system // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora / Anić, Branimir (ur.). 2023. str. 19-19

Podaci o odgovornosti

Baretić, Maja

engleski

Stress and the endocrine system

Stress as a state of unbalanced homeostasis, triggered by intrinsic or extrinsic agents that affect physiologic and behavioral responses aiming to get optimal body balance. Stress affects all systems of the body, as well as endocrine glands. The main parts of the endocrine system involved in the response to stress are the hypothalamic- pituitary-adrenal axis and the autonomic nervous system which interact with other parts of the central nervous system and peripheral organs. The catecholamine hormones epinephrine and norepinephrine reacted rapidly to stress being secreted from the adrenal medulla. They have numerous effects on behaviour, metabolism, and the cardiovascular system and their response is commonly termed the fight-or-flight-or-freeze response. The glucocorticoid hormones are released from the adrenal cortex interacting with intracellular receptors and initiating gene transcription. It means that glucocorticoids have a delayed, but more sustained effect than catecholamines. The glucocorticoids orchestrate a wide array of responses to the stressor. They have direct effects on behavior, metabolism and energy exchange, reproduction, growth, and the immune system. Stress can also lead to changes in the serum level of many other hormones like growth hormone and prolactin. Numerous endocrine disorders can be caused and/or worsened by stressors like gonadal dysfunction, psychosexual dwarfism, and obesity. Exposure to endogenous or exogenous stress can also alter the clinical status of many preexistent endocrine disorders such as precipitation of adrenal crisis and thyroid storm. The aim of hormonal response to stress is to pull together adaptive responses against the specific agent that triggers tension. If a response to stress is deficient or excessive it can result in psychological pathology and alerted endocrine response. Even more, under conditions of long-term stress, the glucocorticoid-mediated effects become maladaptive and can lead to disease. Long-term exposure to common stress in experimental animals showed epigenetic changes in DNA influencing how genes that control mood and behaviour are expressed.

stress ; endocrine system ; hypothalamic-pituitary-adrenal axis

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Podaci o prilogu

19-19.

2023.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora

Anić, Branimir

Zagreb:

0024-3477

1849-2177

Podaci o skupu

18th Croatian Student Summit - CROSS

predavanje

25.04.2023-28.04.2023

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti