engleski

Association of optical parameters with TSH, thyroid hormones and thyroglobulin levels

The aim of this study was to determine whether 24 optical parameters were associated with thyroid- stimulating hormone (TSH), thyroid hormones and thyroglobulin (Tg) levels. It is well known that in some pathological conditions of the thyroid gland, the eyes can also be affected. An example of such a condition is Thyroid Eye disease (or Graves' eye disease). This condition caused by hyperactive thyroid is characterized by an attack of the eye tissues by the immune system which in turn leads to the expansion of eye muscles or fat. In this study, we wanted to examine the association of different optical parameters with TSH, thyroid hormones and Tg levels in a large group of healthy individuals. This cross-sectional study included 4848 healthy adults recruited within the project “10, 001 Dalmatians” which is a part of the Croatian Biobank program. Plasma levels of TSH, free triiodothyronine (fT3), free thyroxine (fT4), and Tg were measured by an immunoassay. In addition, we determined 24 optical parameters for each participant (left and right eye posterior chamber length, eyeball length, IOL1, IOL2, IOL3, corneal thickness, lens thickness, cylinder power, spherical power, angle, anterior chamber depth, corneal radius). Two statistical methods (simple correlation and unsupervised machine learning algorithm ; principal component analysis [PCA]) confirmed the association of different optical parameters with TSH, thyroid hormones and Tg levels in healthy individuals. This study should be replicated in individuals with hyperthyroidism while hypothyroidism could clarify the physiological background of our results and give us explanations of the associations obtained.

Optical parameters ; thyroglobulin ; thyroid

nije evidentirano