engleski

Possible influence of statins on the paraoxonase activity

Introduction: Paraoxonase(PON 1) is a serum esterase which is supposed to be connected with the antioxidative role of HDL cholesterol. The aim of our study was to investigate whether the activity of this enzyme could be modified by the statin therapy. Material and Methods: We investigated the activity of PON1 in 50 patients with types IIa and IIb hyperlipoproteinemias, of both sexes, aged 30-70 years, with the LDL concentration higher than 4.2 mmol/L who did not receive any treatment that could influence the results obtained, for at least one year prior to the study. If the normalisation of lipid status has not been achieved by diet and increased physical activity after a 9-week period, the therapy with 20 mg of simvastatin was started. Blood samples were collected before, 3 and 6 months after the beginning of the statin treatment. Results: Our results showed that PON 1 activity has not been significantly changed due to simvastatin treatment. Nevertheless, the activity of this enzyme has been slightly increased, but more in patients with type IIb hyperlipoproteinemia. An inverse correlation between PON 1 activity and LDL and HDL2 concentrations was also observed. Conclusions: The results of the study show a possible role of the PON 1 in the process of the reverse cholesterol transport and the possible influence of the statin treatment in modifying the activity of this enzyme.

paraoxonase; HDL-cholesterol; hyperlipoproteinemia; statins

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