engleski

Assessment of internal derangement of the temporomandibular joint according to the concentration of salivary cytokines in patients with spondyloarthritis

Spondyloarthritis (SpA) is a group of autoinflammatory/autoimmune diseases that affects the spine and peripheral joints. Involvement of the cervical spine correlates with occurrence of temporomandibular disorders (TMDs). Proinflammatory cytokines, interleukin (IL)-23, IL-17A, and tumour necrosis factor-alpha (TNF-α) are significantly involved in the immunopathogenesis of SpA, and inflammation is one of the causes of TMDs. We hypothesised that internal derangement (ID) of temporomandibular joints (TMJs), as the most frequent TMDs in patients with SpA, could be associated with salivary pro-inflammatory markers and clinical activity of axial SpA, measured with laboratory methods or rheumatological indexes. If a statistically significant difference in the concentration of salivary IL-23, IL-17A or TNF-α exists between patients with symptomatic or asymptomatic ID and patients without TMDs, the diagnostic accuracy of certain cytokine(s) for ID can be calculated. The diagnostic accuracy of the cytokine(s) could emphasise the inflammatory background of ID and possibly broaden therapeutic approaches for symptomatic ID in patients with SpA with biological drugs in addition to the routine application of occlusal splint and/or physical therapy.

internal derangement ; interleukin-23 ; interleukin-17 ; spondyloarthritis ; temporomandibular joint disorders ; tumour necrosis factor-alpha

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