engleski

Serum calprotectin and CRP concentrations in COVID- 19 disease

BACKGROUND-AIM The aim of this study was to evaluate the usefulness of serum calprotectin (sCAL) determination as well as the relationship between sCAL and CRP levels considering activity and severity of COVID-19. Both sCAL and CRP play important roles in the inflammatory response and could give different perspective on the course of the disease. METHODS Study included 143 subjects (70 female and 73 male) divided into four groups: patients that needed intensive care and mechanical ventilation (IC group, N=48), non- critical patients with oxygen treatment (RC group, N=22), patients in postcovid follow-up (PC, N=39) and healthy controls (HC, N=34). sCAL and CRP were determined on the AU5800 analyser (Beckman Coulter, Tokyo, Japan) Kruskal-Wallis and correlation analysis were used to test differences and connection between sCAL and CRP using MedCalc Statistical Software version 18.11.6 (MedCalc Software Bvba, Ostend, Belgium). RESULTS Median concentration with interquartile ranges were as follows: 6.27 [1.58-21.78] mg/L for sCAL and 100.4 [12.5-210.9] mg/L for CRP in IC group ; 5.04 [1.43-12.31] mg/L for sCAL and 69.3 [7.5-389.2] mg/L for CRP in RC group ; 1.68 [0.52-3.02] mg/L for sCAL and 2.2 [0.3-27.9] mg/L for CRP in PC group ; 0.68 [0.31 - 1.59] for sCAL and 1.3 [0.4- 16.4] for CRP in HC group. We found statistically significant differences for both sCAL and CRP between tested groups (P<0.001). Post-hoc analysis showed significant difference in CRP between hospitalized patients (IC and RC group) and non- hospitalized subjects (PC and HC group). sCAL showed similar statistics with one difference: sCAL was statistically higher in PC group than in the HC group (p<0.001) although these subjects were no longer in the acute phase of inflammation. sCAL showed a good positive correlation with CRP (r=0.64, P<0.001) CONCLUSIONS Our results showed that subjects with a severe course of the disease (IC and RC) had higher sCAL and CRP than subjects in postcovid or healthy group which defines sCAL as a useful biomarker that can predict the severity of COVID-19 disease. sCAL is also higher in postcovid group than in the healthy control group suggesting that the two tested markers do not follow the same dynamics in the acute inflammation that sCAL can be useful as a marker in the recovery period.

calprotectin ; CRP ; COVID-19 ; serum ; biomarker

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