engleski

IgG N-glycosylation is not influenced by severity of complications in type 1 diabetes

N-glycosylation of immunoglobulin G (IgG) is known to influence the antibody function. Changes in IgG N-glycome associate with many inflammatory conditions and were reported in early stages of type 1 and type 2 diabetes mellitus (DM). IgG N- glycosylation was also studied in relation to disease progression in type 2 DM and was found to associate with diabetes complications. Although type 1 and type 2 DM share complications, these findings may not apply to type 1 DM due to different pathophysiology involved and a longer disease duration prior to complication manifestation.

glycosylation, N-glycosylation, IgG, diabetes, type 1

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