engleski

Biodegradable composite materials as scaffolds and drug delivery systems for bone tissue engineering application

The malignant diseases frequently affect the population of early and middle age and represent a high burden to healthcare system in the last few decades. [1] The development of less invasive smart materials as drug delivery systems has emerged from the need for advanced procedures of tumor treatment. The targeted drug delivery ensures localized treatment of tumor tissue minimizing the exposure of the whole body. [2] The innovative drug delivery approach lies in a less invasive treatment by the combination of biodegradable polymer, metal ions and antitumor drug in order to administrate lower drug dosage. The use of transition metal ions, such as copper, will inhibit the growth of tumor cells through their redox activity in living organisms. [3] The biocompatible and biodegradable materials such as pH-sensitive chitosan-based carriers are exceedingly promising systems for the encapsulation and simultaneous release of antitumor drug and therapeutic metal ions that will act synergistically to inhibit the growth and survival of tumor cells under lower concentration of the drug. Natural human bone is a metabolically active tissue that undergoes continuous process of formation, resorption and remodeling. When it comes to small defects of damage, bone possesses the self-healing ability. [4] However, larger defects originated from surgical resection of tumor require implants, i.e. scaffolds that serve as a support for tissue regeneration and tumor inhibition. Furthermore, highly porous chitosan- based scaffolds modified by bioactive agents can be developed as dual functional carriers that will provide simultaneous antitumor activity to inhibit bone tumor and to induce tissue regeneration at defect site.

Bone tissue engineering ; Drug delivery ; Scaffold ; Microspheres

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