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Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review (CROSBI ID 324728)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Mitrović, Joško ; Hrkač, Stela ; Tečer, Josip ; Golob, Majda ; Ljilja Posavec, Anja ; Kolar Mitrović, Helena ; Grgurević, Lovorka Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review // Biomedicines, 11 (2023), 5; 1-28. doi: 10.3390/biomedicines11051262

Podaci o odgovornosti

Mitrović, Joško ; Hrkač, Stela ; Tečer, Josip ; Golob, Majda ; Ljilja Posavec, Anja ; Kolar Mitrović, Helena ; Grgurević, Lovorka

engleski

Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review

Rheumatoid arthritis (RA) is among the most prevalent and debilitating autoimmune inflammatory chronic diseases. Although it is primarily characterized by destructive peripheral arthritis, it is a systemic disease, and RA- related extraarticular manifestations (EAMs) can affect almost every organ, exhibit a multitude of clinical presentations, and can even be asymptomatic. Importantly, EAMs largely contribute to the quality of life and mortality of RA patients, particularly substantially increased risk of cardiovascular disease (CVD) which is the leading cause of death in RA patients. In spite of known risk factors related to EAM development, a more in-depth understanding of its pathophysiology is lacking. Improved knowledge of EAMs and their comparison to the pathogenesis of arthritis in RA could lead to a better understanding of RA inflammation overall and its initial phases. Taking into account that RA is a disorder that has many faces and that each person experiences it and responds to treatments differently, gaining a better understanding of the connections between the joint and extra-joint manifestations could help to create new treatments and improve the overall approach to the patient.

rheumatoid arthritis ; pathogenesis ; inflammation mediators

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Podaci o izdanju

11 (5)

2023.

1-28

objavljeno

2227-9059

10.3390/biomedicines11051262

Povezanost rada

Kliničke medicinske znanosti

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