hrvatski

Utjecaj zaštine skupine na konformaciju ferocenskog konjugata s valinom

The biochemical properties of D-amino acids, as well as peptides containing D-amino acids, are of great interests because of their toxic, protective, or signalling effect. [1] To date, very few ferrocene peptides based on D-amino acids have been studied. [2, 3] Here, we synthesized the bioconjugates Boc-D-Val-NH-Fn-COOMe (1) and Ac-D- Val-NH-Fn-COOMe (2) (Ac = acetyl, Boc = tert- butoxycarbonyl). To determine whether the branched isopropyl side chain of valine and the protecting groups affect the intramolecular hydrogen bonding (Figure 1), i.e., their conformational behaviour, we performed a detailed spectroscopic analysis (IR, NMR and CD), followed by a crystallographic and DFT study.

D-aminokiseline, D-valin, ferocen, konformacijska analiza

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