Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Interaction of Copper(II) Complexes of Bidentate Benzaldehyde Nicotinic Acid Hydrazones with BSA: Spectrofluorimetric and Molecular Docking Approach (CROSBI ID 324375)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Zahirović, Adnan ; Osmanković, Irnesa ; Osmanović, Amar ; Višnjevac, Aleksandar ; Magoda, Amina ; Hadžalić, Selma ; Kahrović, Emira Interaction of Copper(II) Complexes of Bidentate Benzaldehyde Nicotinic Acid Hydrazones with BSA: Spectrofluorimetric and Molecular Docking Approach // Acta chimica slovenica, 70 (2023), 1; 74-85. doi: 10.17344/acsi.2022.7826

Podaci o odgovornosti

Zahirović, Adnan ; Osmanković, Irnesa ; Osmanović, Amar ; Višnjevac, Aleksandar ; Magoda, Amina ; Hadžalić, Selma ; Kahrović, Emira

engleski

Interaction of Copper(II) Complexes of Bidentate Benzaldehyde Nicotinic Acid Hydrazones with BSA: Spectrofluorimetric and Molecular Docking Approach

Two copper(II) complexes of 4-chloro- and 4- dimethylaminobenzaldehyde nicotinic acid hydrazones were prepared and characterized by elemental analysis, mass spectrometry, infrared and electron spectroscopy and conductometry. These rare examples of bis(hydrazonato)copper(II) complexes are neutral complex species with copper(II) center coordinated with two monoanionic bidentate O, N-donor hydrazone ligands coordinated in enol-imine form. The interaction of hy-drazone ligands and corresponding copper(II) complexes with CT DNA and BSA was investigated. Copper(II) complex-es are slightly effective in binding the DNA than pristine hydrazones. The results indicate groove binding or moderate intercalation which are not significantly affected by the nature of substituent at hydrazone ligands. On contrary, affinities of two copper(II) complexes toward BSA significantly differs and depends on the nature of the substituent, however in absence of thermodynamic data difference in nature of binding forces cannot be excluded. The complex bearing elec-tron-withdrawing 4-chloro substituent has larger affinity toward BSA compared to 4- dimethyamino analogue. These findings were theoretically supported by molecular docking study.

Copper, nicotinic acid, hydrazone, bidentate, CT DNA, BSA

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

70 (1)

2023.

74-85

objavljeno

1318-0207

1580-3155

10.17344/acsi.2022.7826

Povezanost rada

Kemija

Poveznice