engleski

Sterigmatocystin – an extraordinary mycotoxin

Sterigmatocystin (STC) is a polyketide-derived mycotoxin structurally related to aflatoxin B1 (AFB1). Various research pointed to the notable differences in their toxic potencies, biotransformation, and mode of action. Our recent study showed that STC forms a stable aggregate in aqueous solutions in a concentration- dependent manner. Interestingly, none of the sibling molecules, including AFB1 or 5-methoxysterigmatocystin (MET-STC), do not share this property. In addition, the circular dichroism spectrum of exceptionally high intensity yielded from the STC aqueous aggregate had never been documented for any other small molecule. In the presented research it will be demonstrated how this phenomenon can be implemented in the research of STC and why it absolutely must be considered. Special emphasis will be put on the interactions of STC with different biomacromolecules

aggregate ; hydrophobic interactions ; mycotoxins ; noncovalent interactions ; spectroscopy

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