engleski

The effect of medical Manuka honey in thetreatment of periodontitis: Split-mouth study

Periodontitis is the most common diseasesaffecting the world's population. Initial-non-surgical therapy is the firststep in the treatment of periodontitis. Besides the initial therapy, addi- tional methods can be applied. Recently, the interest shifted to alterna-tive treatments, from which bacteria could not develop any resistance, and one of these could be Manuka honey. It is an endemic type ofhoney produced in Australia which has a wide range of effects on bacte-ria, viruses and fungi. Therefore, the aim of the study is to compare out-comes of the non- surgical initial therapy with or without additionaltopical application of compounds containing Manuka honey. Methods: In this split-mouth study, a total of 12 participants withstage III periodontitis underwent full-mouth non-surgical therapy.Manuka honey was applied in two randomly determined quadrants ofthe oral cavity. The effectiveness of Manuka honey was investigatedby measuring the clinical parameters of periodontal disease (bleedingin probing, probing depth, plaque index, recession) at four time-points, i.e. before the non-surgical therapy, and after 3, 6 and 12 months.Results: Statistically significant differences in CAL gain and PPDreduction were identified after 3, 6 and 12 months. After 3 monthsPPD reduction in Manuka treated sites was 1.46 and in untreated1.25. CAL gain was respectively 1.38 (Manuka) 1.2 (untreated). After6 months PPD reduction was 1.71 (Manuka) 1.41 (untreated). CALgain 1.61 (Manuka) 1.33 (untreated). After 12 months PPD reductionwas 1.74 (Manuka) 1.55 (untreated) and CAL gain 1.64 (Manuka) 1.48(untreated).Conclusions: Despite the small number of participants involved in thispilot study, the use of Manuka honey showed a promising potentialfor being used as an adjunctive therapy to NST. The improvements inoutcomes were modest, but statistically significant, for sitesadjunctively treated with Manuka in terms of PPD reduction and CALgain after each of the follow-up time points.

Manuka honey, non-surgical peridontal treatment

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