engleski

Determination of molecular and crystal structure of Schiff bases with quinazoline

A substituted imine, a nitrogen analog of a ketone or aldehyde where the carbonyl ( C=O) group is replaced by an imine (C=N) group, a carbon-nitrogen double bond is called a Schiff base. The reaction where aminobenzoic acids and dialdehydes can be used as reactants is a reversible reaction it is called Schiff base synthesis. Two primary factors control the efficiency of the above reactions and have a significant effect on utilization. Slightly acidic conditions are necessary, where water can disappear, which means that the acid concetration must not be increased ( pH between 3 and 5), otherwise, if the solution is too acidic, the protonation of the amine will occur, which will inhibit the first stage and the reaction will not be able to continue. Heterocyclic compounds that are made from a fused pyrimidine and benzene ring are called quinazolines. The properties of substituted quinazoline derivatives largely depend on the nature of the substituent itself. In this thesis, three Schiff bases with a quinazoline substituent were crystallized and their crystal and molecular structures were determined.

Schiff bases; aminobenzoic acids; dialdehydes

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