engleski

QUALITATIVE AND QUANTITATIVE HISTOLOGIC COMPARISON OF SYNTHETIC BIOMATERIAL AND XENOGRAFT IN ALVEOLAR RIDGE AUGMENTATION

Aim: In the case of atrophy of the alveolar ridge, hard and soft tooth tissues are damaged. Many biomaterials are used for bone regeneration, such as allografts, xenografts, autogenous bone and synthetic biomaterials. The aim of this research is to gain insights into the regenerative potential of injectable biphasic calcium phosphate (I-BCP). The hypothesis of the study is that I-BCP achieves approximately the same effect in the percentage of new bone formation (NB) compared to xenograft and has an equal histocompatibility. Materials and methods: The study included 38 subjects divided into two groups. After tooth extraction, the socket in the test group was filled with I-BCP, and in the control group, the socket was filled with xenograft. After six months of healing, a biopsy was performed. In the pathohistological analysis, the response of the tissue to the biomaterial was evaluated, while the percentage of NB, residual biomaterial and soft tissue was determined histomorphometrically. Results: Qualitative results of both biomaterials showed osteocytes in NB, while osteoblasts were found at the interface between NB and residual biomaterial. The proportion of NB was 39.91 ± 8.49 % for I-BCP, residual biomaterial 28.61 ± 11.38 % and soft tissue proportion 31.49 ± 11.09 %. The proportion of NB in xenograft was 41.73 ± 13.99 %, residual biomaterial 31.72 ± 15.52 %, while the soft tissue proportion was 26.54 ± 7.25 %. Conclusion: We can conclude that there is no statistically significant difference between the examined and the control group regarding NB (p = 0.629).

Alveolar ridge augmentation ; Biocompatible materials ; Calcium phosphate ; Bone regeneration

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