engleski

Incidence of hypokalemia during therapy with abirateron acetate - real clinical practice data

Abirateron acetate (AA) selectively inhibits the CYP17 enzyme resulting in a decrease in androgen synthesis in the adrenal glands, testicles and prostate tissue. Inhibition of CYP17 reduces serum cortisol levels and increases ACTH secretion through negative feedback loop, which can lead to mineralocorticoid excess and cause hypokalemia, fluid retention and hypertension. Results show that in real clinical practice, AA therapy with prednisone coadministration does not lead to a significant suppression of serum cortisol levels and recurrent meneralocorticoid excess. On the other hand, a possible influence on the low incidence of hypokalemia is an angiotensin converting enzyme inhibitor (ACEi) therapy that was present in 13 (36%) patients due to comorbidity. In view of possible more severe forms of hypokalemia, especially in patients after docetaxel therapy and coadministration of ACEi and/or diuretics, serum potassium value should be monitored according to recommendations.

abirateron acetate, metastatic castration-resistant prostate cancer, hypokalemia

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