Proteins in urine - possible biomarkers of endometriosis (CROSBI ID 323380)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Višnić, Alenka ; Čanadi Jurešić, Gordana ; Domitrović, Robert ; Klarić, Marko ; Sušanj Šepić, Tina ; Barišić, Dubravko
hrvatski
Proteins in urine - possible biomarkers of endometriosis
In the pathogenesis of endometriosis, a number of pathological reactions occur. Proteins secreted in the urine are thought to interact with each other and stimulate the pathological processes in endometriosis. Identifying one or more proteins that are specific enough and could serve as biomarkers for endometriosis is both a challenge and a necessity that would facilitate diagnosis. The urine of patients treated in a tertiary university hospital between July 1, 2020 and June 30, 2021 was analyzed. The studied group consists of patients who were treated surgically for endometriosis and in whom the diagnosis was confirmed by pathohistological analysis. The control group consists of patients who were operated for functional ovarian cysts. Urinary proteins were analyzed by chromatography and mass spectrometry (LC-MS / MS). We identified 17 proteins in urine whose concentrations were statistically significantly different in the group with endometriosis (N=16) compared with the control groups (N=16). The detected proteins were classified into groups according to their function in invasion, migration and proliferation, proteolysis, immune system, cell adhesion and vascular system. For all mentioned proteins the difference in concentration is statistically significant p < 0.005. Proteins are secreted in the urine of patients with endometriosis that may be involved in the pathogenesis of the disease and are possible biomarkers for endometriosis.
endometrioza, spektrometrija masa, proteini, urin
nije evidentirano
engleski
Proteins in urine - possible biomarkers of endometriosis
nije evidentirano
endometriosis, mass spectrometry protein, urine
nije evidentirano
Podaci o izdanju
157 (-)
2023.
103941
10
objavljeno
0165-0378
10.1016/j.jri.2023.103941